(A) UMAP visualization of PBMCs from adenovirus-triggered RIME using single-cell multiomics. (B) UMAP visualization of monocyte subclusters in active disease versus recovered samples. (C) Volcano plot of differentially expressed genes in classical monocytes comparing active disease to recovered. Genes with a –log₁₀-adjusted P value of greater than 1.3 (adjusted P < 0.05) and an absolute log₂(fold change) of greater than 0.5 are highlighted in red. Statistical significance was determined using the quasi-likelihood F test. (D) Dot plot of ligand-receptor interactions involving classical monocytes in active disease. Color and dot size represent the mean of expression levels of interacting molecules. Significant interactions (P < 0.05) are highlighted with a black dot border. (E) Clinical photographs of patients with active RIME. (F) Multiplex protein analysis clustergram of 30 proteins with highest variability compared with healthy controls. Variance depicted with +4 maximum (red) and –4 minimum (blue). Hierarchical clustering using dendrograms clustered similar patient samples and analytes. (G) Volcano plot depicts statistically significant analytes when comparing patients to healthy controls. Dashed vertical lines: 2-fold change; dashed horizontal line: P < 0.05, (2-sided unpaired t test, false discovery rate adjusted).