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Videos

Urinary markers of acute interstitial nephritis

In this episode, Chirag Parikh and colleagues demonstrate that urine TNF-α and IL-9 levels improve prebiopsy diagnosis of acute interstitial nephritis.

 


MacSpectrum platform decodes macrophage heterogeneity

In this episode, Beiyan Zhou, Chuan Li, and colleagues describe the development and application of single-cell transcriptomics-based MacSpectrum, which enables fine-mapping of monocyte/macrophage heterogeneity in healthy and disease states.


Long-term trial supports CD19-targeted CAR T cells for relapsed/refractory CLL

In this episode, Mark Geyer and colleagues demonstrate that second-generation CD19-targeted CAR T cell therapy following conditioning chemotherapy is tolerated and can produce complete remission in a subset of relapsed/refractory CLL patients.


Ovarian cancer microenvironment promotes suppressor functions in mature neutrophils

In this episode, Kelly Singel and colleagues reveal that mature neutrophils acquire a suppressive phenotype in the ovarian cancer microenvironment that is linked to complement C3 activation.


Complement receptor C3aR1-mediated protection in spinal cord injury

In this episode, Marc Ruitenberg and colleagues demonstrate that complement receptor C3aR stimulates PTEN to inhibit neutrophil-mediated inflammatory pathology following traumatic spinal cord injury.

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